Table 6. 72 h IC550 Values of 3D7 vs MFR3-Q487E (3D7 Background) and Dd2 vs MFR3-D150V (Dd2 Background) against Antimalarial Compounds.
| IC50 | 3D7 | MFR3-Q487E | Dd2 | MFR3-D150V |
|---|---|---|---|---|
| MMV085203 (nM) | 152.7 ± 25.8 | 438.4 ± 40.8 | 47.6 ± 6.8 | 78.6 ± 21.9 |
| GNF-Pf-3600 (nM)a | 96.1 | 476.6 | 21.7 ± 8.6 | 60.8 ± 15.9 |
| atovaquone (nM) | 0.585 ± 0.11 | ±0.09 | 0.546 ± 0.11 | 0.497 ± 0.21 |
| artemisinin (nM) | 21.7 ± 4.3 | 19.5 ± 0.95 | 15.4 ± 2.8 | 12.9 ± 5.6 |
| chloroquine (nM) | 70.2 ± 51.2 | 71.4 ± 54.9 | 556.8 ± 197.6 | 556.1 ± 224.2 |
| epoxomicin (nM) | 10.1 ± 1.8 | 9.82 ± 1.8 | 10.1 ± 2.6 | 8.17 ± 0.15 |
| brefeldin A (μM) | 1.71 ± 0.09 | 1.63 ± 0.11 | 2.13 ± 0.25 | 1.94 ± 0.26 |
| KDU691 (nM) | 45.0 ± 5.74 | 44.4 ± 2.19 | 41.7 ± 3.0 | 42.8 ± 7.2 |
| KAF156 (nM) | 6.68 ± 0.38 | 7.60 ± 0.10 | 10.7 ± 0.51 | 9.6 ± 0.73 |
| cycloheximide (nM) | 202.9 ± 53.2 | 174.4 ± 34.3 | 152.2 ± 80.3 | 135.3 ± 47.5 |
| actinomycin D (nM) | 3.74 ± 0.67 | 3.58 ± 0.55 | 1.98 ± 0.2 | 1.73 ± 0.3 |
a
Only one biological replicate.