Table 3.
Sensitivity, specificity, PPV, NPV, and overall accuracy of Ada and Rheport for the diagnosis of inflammatory rheumatic diseases including 95% confidence intervals
| Characteristic | Symptom checker | |||
|---|---|---|---|---|
| Rheport | Ada D1 | Ada D5 | ||
| Total sample (n = 164) | Sensitivity (%) | 53.7 (39.7–67.2) | 42.6 (29.5–56.7) | 53.7 (39.7–67.2) |
| Specificity (%) | 51.8 (42.1–61.4) | 63.6 (53.9–72.4) | 54.5 (44.8–64.0) | |
| PPV (%) | 35.4 (25.3–46.8) | 36.5 (25.0–49.6) | 36.7 (26.4–48.4) | |
| NPV (%) | 69.5 (58.2–78.9) | 69.3 (59.2–77.9) | 70.6 (59.6–79.7) | |
| Accuracy (%) | 52.4 (44.5–60.2) | 56.7 (48.8–64.3) | 54.3 (46.3–62.0) | |
| Ada first (n = 164) | Sensitivity (%) | 56.0 (35.3–75.0) | 40.0 (21.8–61.1) | 60.0 (38.9–78.2) |
| Specificity (%) | 52.6 (39.1–65.8) | 61.4 (47.6–73.7) | 54.4 (40.8–67.4) | |
| PPV (%) | 34.1 (20.6–50.7) | 31.2 (16.7–50.1) | 36.6 (22.6–53.1) | |
| NPV (%) | 73.2 (56.8–85.2) | 70.0 (55.2–81.7) | 75.6 (59.4–87.1) | |
| Accuracy (%) | 53.7 (42.4–64.6) | 54.9 (43.5–65.8) | 56.1 (44.7–66.9) | |
| Rheport first (n = 164) | Sensitivity (%) | 51.7 (32.9–70.1) | 44.8 (27.0–64.0) | 48.3 (29.9–67.1) |
| Specificity (%) | 50.9 (37.0–64.7) | 66.0 (51.6–78.1) | 54.7 (40.6–68.2) | |
| PPV (%) | 36.6 (22.6–53.1) | 41.9 (25.1–60.7) | 36.8 (22.3–54.0) | |
| NPV (%) | 65.9 (49.3–79.4) | 68.6 (54.0–80.5) | 65.9 (50.0–79.1) | |
| Accuracy (%) | 51.2 (40.0–62.3) | 58.5 (47.1–69.1) | 52.4 (41.2–63.5) | |
Ada D1, using Ada top suggestion only; Ada D5, using all suggestions provided by Ada; PPV, positive predictive value; NPV, negative predictive value