Table 1.

Summary of included randomized controlled trials

Author	Year	Procedure	Number treatment/control	Intervention/control	Infusion duration	Type of anesthesia	Adverse events
De Oliveira et al. (De Oliveira et al., 2012)	2012	Gynecological laparoscopy	35/35	1.5 mg/kg lidocaine bolus with 2 mg/kg/h infusion 0.9% normal saline	End of surgery	Sevoflurane	None
Dewinter et al. (Dewinter et al., 2016)	2016	Laparoscopic sterilization	39/40	1.5 mg/kg lidocaine bolus with 1.5 mg/kg/h infusion 0.9% normal saline	30 min after surgery	Sevoflurane	None
Lauwick et al. (Lauwick et al., 2008)	2008	Laparoscopic cholecystectomy	25/24	1.5 mg/kg lidocaine bolus with 1.5 mg/kg/h infusion 0.9% normal saline	End of surgery	Desflurane	(1) Persistent hypertension, (1) rapid atrial fibrillation
McKay et al. (McKay et al., 2009)	2009	Laparoscopic endocrine/breast/gynecology/minor orthopedic	29/27	1.5 mg/kg lidocaine bolus with 2 mg/kg/h infusion 1.5 mg/kg lidocaine bolus 0.9% normal saline infusion	60 min after surgery	Sevoflurane Desflurane Isoflurane	(1) Dizziness and visual disturbances
Ortiz et al. (Ortiz et al., 2016)	2016	Laparoscopic cholecystectomy	21/22	1.5 mg/kg lidocaine bolus with 3 mg/kg/h infusion 0.9% normal saline infusion	60 min after surgery	Isoflurane	None