Table 2.
The correlation between miR-221-3p expression levels and clinic characteristics based on TCGA database
| Clinicopathological features | Terms | n | Mean ± SD | p-value |
|---|---|---|---|---|
| Unpaired tissue | Normal | 44 | 8.16 ± 0.64 | 0.001 |
| HNSCC | 480 | 8.55 ± 0.78 | ||
| Sex | Male | 383 | 8.45 ± 0.79 | 0.001 |
| Female | 141 | 8.71 ± 0.68 | ||
| Age | < 60 | 234 | 8.50 ± 0.76 | 0.559 |
| > = 60 | 290 | 8.54 ± 0.78 | ||
| lymphovascular invasion | NO | 232 | 8.54 ± 0.81 | 0.429 |
| YES | 292 | 8.49 ± 0.75 | ||
| Neoplasm histologic grade | G1-G2 | 371 | 8.49 ± 0.73 | 0.260 |
| G3-G4 | 156 | 8.58 ± 0.82 | ||
| M stage | M0 | 498 | 8.51 ± 0.78 | 0.967 |
| M1 | 29 | 8.51 ± 0.57 | ||
| N stage | N0 | 246 | 8.53 ± 0.76 | 0.572 |
| N1-N3 | 281 | 8.49 ± 0.77 | ||
| Alcohol | NO | 164 | 8.62 ± 0.76 | 0.047 |
| YES | 363 | 8.48 ± 0.76 | ||
| HPV status | Negative | 194 | 8.41 ± 0.81 | 0.066 |
| Positive | 330 | 8.55 ± 0.81 | ||
| Perineural invasion | NO | 198 | 8.53 ± 0.81 | 0.693 |
| YES | 329 | 8.50 ± 0.80 |
Notes: HNSCC, Head and neck squamous cell carcinoma; T stage, size or direct extent of the primary tumor; N stage, degree of spread to regional lymph nodes; M stage, presence of distant metastasis; SD, standard deviation