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. 2021 Apr 13;22:104. doi: 10.1186/s13059-021-02331-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Effects of PD-L1-lnc on the growth of lung cancer xenografts in mice. a Change in body weight throughout the experiment. b Change in tumor volume. c The size and weight of various tumors 30 days post-engraftment. Scale bar, 1 cm. d Proliferation of implanted tumors. Upper: representative immunohistochemical staining of Ki67 in implanted tumors; Lower: quantitative analysis. Scale bar, 100 μm. e RT-PCR analysis of the expression levels of PD-L1-lnc in the implanted tumors. Upper: gel image of PCR product; Lower: RT-PCR analysis. NS, no significance; *P < 0.05; **P < 0.01; ****P < 0.0001