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. 2020 Nov 3;38(4):1276–1291. doi: 10.1093/molbev/msaa286

Fig. 2.

Fig. 2.

The retention and loss of SLC2 genes in different vertebrate clades. (A) SLC2 gene loss and retention in amniota species. Birds completely lost SLC2A4 appearing to result from a clade-specific gene deletion in the avian lineage, or within an archosaur organism within the dinosaurian/avian lineage ancestral to extant birds. Mammals totally lost SLC2A15–20 but independently duplicate SLC2A7 (also SLC2A14 in human). (B) Proportion of missing genes in vertebrate clades. Mann–Whitney test is used to compare differences on variant SLC2 genes. *P value <0.05, **P value <0.01, and ***P value <0.0001. (C) Significantly negative correlation between the proportion of missing genes and vertebrate SLC2 gene age (rate of evolution for nucleotide substitution). (D) Significantly negative correlation excluding certain SLC2 genes only in one lineages(SLC2A7, 14, 18, 19, and 20). Linear regression is used to test the above correlations. “Ma” represents million years ago.