Table 8.

Treatment characteristics and mean dosimetric parameters in publications for accelerated partial breast irradiation (APBI) with CyberKnife

Publication	Xu 201225	Vermeulen 201451	Goggin 201526	Rault 201627	Obayomi 201652	Lozza 201853	Bonfantini 201828	Lee 201829	Lee 202054	Fröhlich 202036	Current study
Patient number	14	21	9	10	10	20	10	10	103	25	32
Applicator	Cones	-	Iris, MLC	Iris	-	Iris	Iris	Cones	-	MLC	MLC
Beam number	-	151	- , -	-	155	180	122	-	-	-	40 (57)@
Fractionation	10 x 3.85 Gy	10 x 3.4 Gy	5 x 6 Gy	10 x 4 Gy	5 x 6 Gy	6 5 Gy x	5 x 6 Gy	5 x 6 Gy	5 x 6 Gy	4 x 6.25 Gy	4 x 6.25 Gy
Treatment Time (min)	-	46	28, 14.7	40	-	60	60	60	33#	-	33.3
CTV-PTV margin (mm)	2	2	2	3	5	5	5	2	0	2	2
Mean PTV volume (cm3)	-	114	-	-	70	88.1	121.6	37.7	73.6	71.6	71.7
Ipsilateral breast
V100 (%)	7#	12	12.5, 12.2		14	28.7		10	-		9.6
V50 (%)	22.4#	26	25.8, 24.2		31	75		24	35.5#		23.3
Ipsilateral non-target breast
V100 (%)	9			-			1.7		-		0.7
V50 (%)	23.1			17.6			16.3		-	10.5	10.5
Ipsilateral lung
V30 (%)	1.3		1.9, 1.6			2.3	2.1		2.2#		1.0
V5 (%)	31.4#		39.4, 17.9								30.7
mean dose (%)											4.9
D0.1cm3										57.5	52.2
D1cm3										45	45.4
Heart
V5 (%)	9.4	10		3.9	31	14	23.2	23	-		21.2
mean dose (%)									2.3#		3.3
D0.1cm3										12.1	18.9
D1cm3										10.5	16.6
Skin
Dmax (%)	-	108.8	-	-	106.6	98.2	94.7	103.3	88.7#	99.6*	88.8*
Contralateral breast
Dmax (%)	1.6	3	-	-	10	-	-	10	2.7#	3.8*	2.1*

* = D0.1cm³; ^# = median value; ^@ = segment number in parentheses; CTV = clinical target volume; MLC = multileaf collimator; PTV = planning target volume