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. 2021 Apr 12;21:396. doi: 10.1186/s12885-021-08158-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Kaempferol downregulation of TGM2 and TGM2 expression is negatively correlated with PDAC prognosis. a Heatmap showing the clustering of the top 50 differentially expressed genes in PANC-1 cells treated with kaempferol (50 μM) and control cells. b and c TGM2 protein levels and mRNA levels in PANC-1 and Mia PaCa-2 cells were decreased by kaempferol treatment compared with those observed in control cells (**P < 0.01, ***P < 0.001). The grouping of blots cropped from different parts of the same gel or from different gels, fields, or exposures was divided with white space. d Left, antitumor activity of kaempferol (100 mg/kg) in nude mice; right, tumor weight. e Tumor sizes were calculated using the following formula: tumor volume = length × (width)2 /2 (P = 0.005). f Total mice weight. g TGM2 expression in xenograft tissue sections was examined by IHC (scale bar, 20 μm). h TGM2 transcription levels were significantly higher in pancreatic cancer tissues than in normal tissues from the GEPIA database (P < 0.01). i TGM2 transcription at different stages (P = 0.15). j and k High TGM2 mRNA expression was correlated with shorter OS (P = 0.011) and DFS (P = 0.000)