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. 2021 Apr 13;19:113. doi: 10.1186/s12957-021-02214-5

Table 3.

Tumor characteristics for all young breast cancer patients according to the time of diagnosis (n = 1099)

2006 2007 2008 2009 2010 2011 2012 2013 2014 P
n = 55 n = 73 n = 96 n = 93 n = 132 n = 154 n = 147 n = 166 n = 183
Tumor size
 T1 21 (38) 27 (37) 39 (41) 37 (40) 45 (34) 64 (42) 49 (33) 62 (37) 76 (42) 0.539
 T2 30 (55) 34 (47) 43 (45) 42 (45) 61 (46) 65 (42) 75 (51) 82 (49) 76 (42)
 T3 2 (4) 3 (4) 5 (5) 5 (5) 16 (12) 13 (8) 15 (10) 12 (7) 17 (9)
 T4 1 (2) 2 (3) 3 (3) 0 (0) 1 (1) 1 (1) 4 (3) 2 (1) 2 (1)
 Tx 1 (2) 7 (10) 6 (6) 9 (10) 9 (7) 11 (7) 4 (3) 8 (5) 12 (7)
Stage 0.004
 I 11 (20) 21 (29) 27 (28) 24 (26) 30 (23) 40 (26) 35 (24) 45 (27) 49 (27)
 II a 24 (44) 20 (27) 37 (39) 36 (39) 41 (31) 47 (31) 56 (38) 51 (31) 71 (39)
 II b 4 (7) 11 (15) 9 (9) 13 (14) 17 (13) 19 (12) 27 (18) 36 (22) 23 (13)
 III a 13 (23) 7 (10) 8 (8) 8 (9) 22 (17) 20 (13) 13 (9) 14 (8) 21 (12)
 III b 0 (0) 2 (3) 0 (0) 0 (0) 0 (0) 0 (0) 2 (1) 2 (1) 2 (1)
 III c 3 (6) 5 (7) 14 (15) 4 (4) 14 (11) 21 (14) 12 (8) 13 (8) 11 (6)
 Unknown 0 (0) 7 (10) 1 (1) 8 (9) 8 (6) 7 (5) 2 (1) 5 (3) 6 (3)
LNM 0.007
 N0 30 (55) 42 (58) 56 (58) 52 (56) 67 (51) 73 (47) 80 (54) 83 (50) 102 (56)
 N1 8 (15) 15 (21) 19 (20) 26 (28) 30 (23) 38 (25) 41 (28) 54 (33) 45 (25)
 N2 13 (24) 11 (15) 6 (6) 10 (11) 19 (14) 20 (13) 12 (8) 15 (9) 18 (10)
 N3 4 (7) 5 (7) 14 (15) 5 (5) 14 (11) 21 (14) 11 (8) 11 (7) 9 (5)
 Unknown 0 (0) 0 (0) 1 (1) 0 (0) 2 (2) 2 (1) 3 (2) 3 (2) 9 (4.9)
HG 0.415
 Well 4 (7) 2 (3) 6 (6) 3 (3) 4 (3) 8 (5) 3 (2) 3 (2) 2 (1)
 Moderately 32 (58) 35 (48) 47 (49) 53 (57) 76 (58) 84 (55) 86 (59) 87 (52) 94 (51)
 Poorly 6 (11) 10 (14) 11 (12) 10 (11) 16 (12) 26 (17) 23 (16) 29 (18) 32 (18)
 Unknown 13 (24) 26 (36) 32 (33) 27 (30) 36 (27) 36 (23) 35 (24) 47 (28) 55 (30)
PT 0.620
 IDC 48 (87) 68 (93) 80 (83) 86 (93) 119 (90) 140 (90) 136 (93) 153 (92) 169 (92)
 ILC 0 (0) 1 (1) 1 (1) 1 (1) 2 (2) 2 (1) 0 (0) 1 (1) 2 (1)
 Others 7 (13) 4 (6) 15 (16) 6 (7) 12 (8) 12 (8) 11 (8) 12 (7) 12 (7)
MS 0.043
 HR+/HER2− 32 (58) 49 (67) 51 (53) 50 (54) 68 (52) 90 (58) 72 (49) 89 (54) 93 (51)
 HR+/HER2+ 9 (16) 9 (12) 7 (7) 5 (5) 9 (7) 21 (14) 15 (10) 22 (13) 23 (13)
 HR−/HER2+ 3 (6) 6 (8) 6 (6) 5 (5) 12 (9) 13 (8) 12 (8) 11 (7) 7 (4)
 HR−/HER2− 8 (15) 6 (8) 20 (21) 26 (28) 33 (25) 16 (10) 28 (19) 27 (16) 37 (20)
 Unknown 3 (6) 3 (4) 12 (13) 7 (8) 10 (8) 14 (9) 20 (14) 17 (10.2) 23 (13)
Final surgery 0.792
 BCS 15 (27) 22 (30) 23 (24) 17 (18) 30 (23) 32 (21) 34 (23) 42 (25) 42 (23)
 Mastectomy 40 (72) 51 (70) 73 (76) 76 (82) 102 (77) 122 (79) 113 (77) 124 (75) 141 (77)

All data are given as no. of patients (%). Percentages may not add up to 100% as a result of rounding

LNM, lymph node metastasis; HG, histological grade; PT, pathological type; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; NACT, neoadjuvant chemotherapy; MS, molecular subtype; BCS, breast conserving surgery