Table 4.
Survival analysis of TEAD4 expression in IDH mutant and IDH wild-type patients
| Data set | IDH mutation status | N | Adjusted HR (95% CI) | Adjusted p |
|---|---|---|---|---|
| OS | ||||
| TCGA-LGG | ALL | 505 | 1.325 (0.867–2.024) | 0.193* |
| IDH mut. | 409 | 2.226 (1.260–3.935) | 0.006** | |
| IDH wt. | 96 | 0.869 (0.473–1.596) | 0.651*** | |
| CGGA-mRNAseq_693 | ALL | 402 | 1.666 (1.201–2.311) | 0.002# |
| LGG | IDH mut. | 306 | 1.805 (1.216–2.679) | 0.003 ## |
| IDH wt. | 96 | 1.218 (0.730–2.031) | 0.450### | |
| DFS | ||||
| TCGA-LGG | ALL | 505 | 1.066 (0.766–1.3482) | 0.706& |
| IDH mut. | 409 | 1.128 (0.759–1.677) | 0.550&& | |
| IDH wt. | 96 | 0.824 (0.455–1.492) | 0.523&&& | |
Note: *Adjusted by age, 1p19q co-deletion, TP53 mutation and tumor grade; **adjusted by age, 1p19q co-deletion and tumor grade; ***adjusted by age and tumor grade; #adjusted by 1p19q co-deletion, IDH mutation and tumor grade; ##adjusted by 1p19q co-deletion and tumor grade; ###adjusted by tumor grade; &adjusted by age, 1p19q co-deletion and TP53 mutation; &&adjusted by 1p19q co-deletion; &&&adjusted by age and ATRX mutation. All covariates were selected by backward stepwise cox regression analysis. The p values reaching to the edge of a significant level (<0.1) were in bold.