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. 2021 Apr 13;19:102. doi: 10.1186/s12951-021-00846-z

Table 2.

Dox pharmacokinetic parameters calculated by a non-compartmental analysis after 3 mg/kg dose of free Dox, LPD and LPF intravenously administered to tumor bearing mice

t1/2 (h) AUC0-∞ (µg h/mL) Cl (mL/h) Vd (mL)
Free Dox 6.99 0.60 99.6 1005.47
LPD 21.83 586.58 0.1 3.15
LPF 11.31 37.96 1.6 25.88

t1/2: Elimination half life; AUC: area under the curve of Dox plasma concentrations vs. time; Cl: total plasma clearance; Vd: volume of distribution; LPD: conventional Dox liposomes; LPF: targeted Dox liposomes; Dox: doxorubicin