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. 2021 Apr 13;21:204. doi: 10.1186/s12935-021-01898-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Morphology of HT-29 and Caco-2 parental adherent monolayer cells and their derived spheroids. Representative phase contrast images from cell lines and their derived spheroids. a Parental HT-29 cells grew as an adherent monolayer, b, c HT-29 derived spheroids cultured at nonadherent and serum free condition showed well-round shape and compact morphology. d Caco-2 parental cells as monolayer and, e, f Caco-2 derived spheroids displayed small and round shape morphology