Table 1.
Single agent OH2 (n=40) |
OH2 with HX008 (n=14) |
|
Median age at entry, years (range) | 55 (27–73) | 53 (36–64) |
Male | 30 (75.0%) | 10 (71.4%) |
Tumor types | ||
Esophageal cancer | 14 | 3 |
Colorectal (including appendix) cancer | 12 | 6 |
Gastric cancer | 5 | 5 |
Melanoma and other skin cancer | 4 | 0 |
Head and neck cancer | 2 | 0 |
Cholangiocarcinoma | 1 | 0 |
Ovarian cancer | 1 | 0 |
Breast cancer | 1 | 0 |
Prior treatment with anti-PD-1 antibodies | 10 (25.0%) | 1 (7.1%) |
Best response (iRECIST) | ||
iPR | 2 | 2 |
iSD | 9 | 4 |
iUPD | 22 | 6 |
iPR, immune-partial response; iRECIST, immune-Response Evaluation Criteria in Solid Tumors; iSD, immune-stable disease; iUPD, immune-unconfirmed progressive disease; PD-1, programmed cell death protein 1.