Table 2.
Treatment-related adverse events
| Adverse events | Single agent OH2 (n=40) |
OH2 with HX008 (n=14) |
||||
| Grade 1 | Grade 2 | Grade 3 | Grade 1 | Grade 2 | Grade 3 | |
| Fever | 10 | 7 | 1 | 1 | 3 | 0 |
| Leukopenia | 3 | 0 | 0 | 0 | 0 | 0 |
| Neutropenia | 2 | 0 | 0 | 0 | 0 | 0 |
| Thrombocytopenia | 1 | 0 | 0 | 0 | 0 | 0 |
| Anemia | 3 | 2 | 0 | 0 | 0 | 0 |
| Hyperbilirubinemia | 1 | 1 | 0 | 0 | 1 | 0 |
| ALT increased | 2 | 0 | 0 | 0 | 0 | 0 |
| AST increased | 2 | 0 | 0 | 0 | 0 | 0 |
| QTc prolongation | 0 | 1 | 0 | 0 | 0 | 0 |
| Pruritus | 1 | 0 | 0 | 0 | 0 | 0 |
| Rash | 2 | 0 | 0 | 0 | 1 | 0 |
| Complications of injection | 0 | 3 | 0 | 0 | 0 | 0 |
| Abdominal pain | 0 | 2 | 0 | 0 | 0 | 0 |
| Diarrhea | 1 | 0 | 0 | 1 | 0 | 0 |
| Nausea | 0 | 1 | 0 | 0 | 0 | 0 |
| Fatigue | 1 | 0 | 0 | 3 | 0 | 0 |
| Myalgia | 1 | 0 | 0 | 0 | 0 | 0 |
| Arthralgia | 1 | 0 | 0 | 0 | 0 | 0 |
| Proteinuria | 0 | 0 | 0 | 1 | 0 | 0 |
| Hypothyroidism | 0 | 0 | 0 | 0 | 1 | 0 |
No grade 4 or 5 treatment-related adverse events occurred in the study.
ALT, alanine aminotransferase; AST, aspartate aminotransferase.