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. 2021 Apr 12;13:77. doi: 10.1186/s13148-021-01052-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Chromosome 7 abnormalities do not affect the methylation status of the EZH2 promoter. DNA methylation levels were determined by bisulfite pyrosequencing in a cohort of MDS/low blast count AML patients. Four-digit numbers represent DNA patient samples. Continuous color gradients represent methylation values between 0% (grey) and 100% (blue). Mean DNA methylation is indicated for each sample. a DNA hypomethylation of the EZH2 promoter in MDS/AML patients. DNA methylation levels of 11 CpGs located within the EZH2 promoter of 60 patients with (n = 11) or without (n = 49) del(7q)/-7 are shown. Peripheral blood lymphocytes (PBL) from a healthy control and the cell lines KG-1, NB-4, and Raji, as well as 0%, 50%, and 100% in vitro methylated DNA served as controls. b DNA methylation of the p15/INK4B (CDKN2B) promoter of MDS patients. DNA methylation levels of 43 CpGs located within the p15/INK4B promoter of 39 patients with (n = 9) or without (n = 30) del(7q)/-7 are shown. c DNA hypermethylation of the NY-ESO-1 promoter of MDS patients. DNA methylation levels of 15 CpGs located within the NY-ESO-1 promoter of 39 patients with (n = 9) or without (n = 30) del(7q)/-7 are shown. PBL from a healthy control, the human myeloma cell line U226, and CD34 + stem cells served as controls