Table 3.
Concentration and distribution of Se in plasma pools before (PK1) and after (PK2) supplementation with SeMet, description of the metabolism of each pool, and putative identification of the pools.
| Plasma pool | Plasma “Diet” concentration (µg/L)1 | Plasma distribution (%) | Description | Putative identification2 | ||
|---|---|---|---|---|---|---|
| PK1 | PK2 | PK1 | PK2 | |||
| 1 | 0.73 ± 0.13 | 1.47 ± 0.19** | 0.5 | 0.5 | Does not pass through liver. Pool size in females 50% of males in PK1 | SeMet |
| 2 | 4.5 ± 0.5 | 10.2 ± 1.0** | 2.7 | 3.8 | Pool size in females 50% of males in PK1. Excretion in urine increased for SeMet | Apo B/lipoproteins—from lymphatics |
| 3 | 2.87 ± 0.62 | 6.12 ± 1.35** | 2.2 | 2.3 | Recycling increased for Sel | Selenosugar1 |
| 4 | 0.16 ± 0.05 | 0.40 ± 0.11* | 0.1 | 0.1 | Increased more in males than females in PK2. Excretion in urine decreased for SeMet | |
| 5 | 1.33 ± 0.35 | 1.87 ± 0.44 | 1.0 | 0.7 | Recycling increased for SeMet | |
| 6 | 1.06 ± 0.26 | 1.04 ± 0.23 | 0.8 | 0.4 | ||
| 7 | 1.28 ± 0.17 | 2.00 ± 0.31* | 1.0 | 0.7 | Recycling increased for SeMet | Selenosugar 3 |
| 8 | 4.00 ± 0.52 | 7.54 ± 0.97** | 3.0 | 2.8 | Doubles in females in PK2. Excretion in urine increased for Sel | |
| 9 | 15.8 ± 1.5 | 29.9 ± 5.3* | 11.9 | 11.1 | Increased 71% in females in PK2. Excretion in urine increased for SeMet | GPx3 |
| 10 | 30.3 ± 3.5 | 69.6 ± 6.5** | 22.8 | 25.9 | Doubles in females in PK2. Excretion in urine increased for Sel | SeP |
| 11 | 72.0 ± 4.6 | 138.5 ± 8.1** | 54.1 | 51.5 | Turnover time is 30 d | Non-specifically incorporated Se (by definition)-albumin |
| TOTAL | 134.0 | 269.0 | 100.0 | 100.0 | ||
*Increased in PK2 vs. PK1, P < 0.05 or **P < 0.01
1Values are calculated by the model ( Supplementary Figure 1 ). To convert µg to µmol multiply by 0.0127.
2Some pools were identified in Wastney et al. (6).