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. 2021 Mar 9;7(4):721–732. doi: 10.1021/acsinfecdis.0c00805

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© 2021 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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WD40 has additive and synergistic activity with antibiotics in P. aeruginosa (strain PA14). Checkerboard assays were used to determine the fractional inhibitory concentrations (FICs) of the tested potentiator-antibiotic pairs. FIC is the MIC of the compound in combination divided by the MIC of the compound alone. Fractional inhibitory concentration indices (FICIs) are calculated by summing FIC_WD40 and FIC_Antibiotic to determine if the pairing is synergistic (FICI ≤ 0.5, blue area in graph), additive (0.5 < FICI ≤ 4.0, gray area in graph), or antagonistic (FICI > 4.0, area not shown in graph). (A, B) Representative graphs of additive potentiator-drug relationships. (C) Representative graph of a synergistic potentiator-drug relationship. Results were reproduced in two independent experiments. For each experiment, n = 1 per concentration combination.