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. Author manuscript; available in PMC: 2022 Apr 8.
Published in final edited form as: J Med Chem. 2021 Mar 22;64(7):3747–3766. doi: 10.1021/acs.jmedchem.0c01810

Table 3:

Kinetics and affinity of enantiomerically pure compounds for disulfide stabilized HIVNL4-3 CA hexamer.

Compound ka (M−1s−1) kd (s−1) KD (nM)
S-PF-74 4.75 ± 0.169 × 105 2.92 ± 0.111 × 10−2 61.5
S-CX15 4.76 ± 0.216 × 105 6.60 ± 0.328 × 10−2 139
S-CX16 4.37 ± 0.158 × 105 1.09 ± 0.043 × 10−2 25
S-CX17 2.86 ± 0.041 × 105 9.66 ± 0.145 × 10−2 337

KD values were derived using the average ka and kd values.