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Top: Design elements found in synthetic mRNA therapeutics. Bottom: Sequence of the COVID-19 mRNA vaccine tozinameran (BNT162b2) from Pfizer/BioNTech. Green: 5′-cap. Yellow: 5′- and 3′-UTR sequences. Blue: SARS-CoV-2 spike glycoprotein coding sequence. Red: Segmented poly(A) tail.
