Table 2.
Prediction of Microbial Etiology by Logistic Regression of Admission Levels of Potential Biomarkers
| Atypical Bacterial vs Typical Bacterial OR (95% CI), P Value | Atypical Bacterial vs Viral OR (95% CI), P Value | Typical Bacterial vs Viral OR (95% CI), P Value | ||||
|---|---|---|---|---|---|---|
| Levels at Admission | Univariate | Multivariatea | Univariate | Multivariatea | Univariate | Multivariatea |
| Hepcidin | 1.64 (0.82–3.28), .16 | 2.64 (0.99–7.02), .053 | 3.12 (1.34–7.28), .008 | 3.22 (1.20–8.64), .020 | 1.68 (1.01–2.77), .044 | 1.16 (0.65–2.06), .62 |
| Ferritin | 2.26 (1.18–4.32), .014 | 3.50 (1.42–8.61), .006 | 2.38 (1.28–4.45), .006 | 2.41 (1.15–5.02), .019 | 1.35 (0.84–2.17), .21 | 0.97 (0.57–1.66), .91 |
| Iron | 0.87 (0.50–1.52), .63 | 0.71 (0.34–1.48), .37 | 0.62 (0.31–1.23), .17 | 0.74 (0.35–1.56), .43 | 0.78 (0.51–1.21), .27 | 1.03 (0.63–1.70), .90 |
| Transferrin | 0.83 (0.48–1.45), .52 | 0.83 (0.44–1.57), .57 | 0.50 (0.26–0.99), .045 | 0.55 (0.26–1.17), .12 | 0.68 (0.44–1.05), .079 | 0.88 (0.55–1.43), .62 |
| Transferrin saturation | 0.94 (0.54–1.65), .83 | 0.84 (0.44–1.57), .58 | 0.86 (0.47–1.60), .64 | 0.97 (0.51–1.85), .93 | 0.94 (0.62–1.42), .76 | 1.07 (0.68–1.69), .76 |
| S-Transferrin receptor | 1.16 (0.67–1.98), .60 | 1.07 (0.59–1.93), .83 | 0.79 (0.42–1.46), .45 | 0.70 (0.35–1.38), .30 | 0.73 (0.48–1.10), .13 | 0.92 (0.59–1.44), .71 |
| CRP | 0.92 (0.59–1.45), .73 | NA | 1.39 (0.80–2.42), .25 | NA | 1.51 (1.01–2.24), .043 | NA |
| Procalcitonin | 0.46 (0.25–0.84), .011 | NA | 1.04 (0.59–1.85), .89 | NA | 2.24 (1.41–3.56), .001 | NA |
Abbreviations: CI, confidence interval; CRP, C-reactive protein; NA, not applicable; OR, odds ratio.
aAdjusted for CRP and procalcitonin.
NOTES: ORs are calculated on basis of ln-transformed and standardized values. Bold indicates P < .05.