Figure 3. The demonstration of the PCA of the selected ligands as compared to Cassiarin D control pharmacophore. Cassiarin D showed a lower eigenvalue, whereas the other five compounds exhibited the highest eigenvalues. Most importantly, Rhinacanthrin D and Exiguaflavanone A revealed the highest eigenvalues, resulting in more stable compounds against ACE2. Besides, the cumulative variance parameter described the positive results of the ligands than the phytochemical Cassiarin D. Eigenvalue (A), variance (B), cumulative variance (C), and principal component analysis (PCA).
