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. 2021 Apr 13;16(4):e0249748. doi: 10.1371/journal.pone.0249748

Fig 1. Specific Wnt pathway genes are differentially expressed in human NIC.

Fig 1

A, qPCR analysis shows that 5 months after injury human NIC tissue has increased levels of Wnt5a mRNA compared to the proximal stump. B, in addition to Wnt5a (p<0.001), qPCR analysis shows that extracellular Wnt modulator Sfrp4, Wnt pathway member Daam1 and the Wnt receptor Ror1 are upregulated. Wnt pathway member Nlk is down regulated. Wnt receptor Fzd8 and Wnt ligand Wnt2 are not differently expressed between the NIC and the proximal stump (* p<0.05, ** p<0.01, *** p<0.001).