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. 2021 Apr 1;17(4):e1009491. doi: 10.1371/journal.ppat.1009491

Fig 4. Bronchial epithelial deficiency of Dnmt3b promotes CXCL1 production by bronchial epithelial cells at the early phase of Pseudomonas pneumonia in vivo.

Fig 4

Dnmt3bfl/flCc10Cre and control Dnmt3bfl/fl mice received flagellin (1 μg) purified from P. aeruginosa intranasally. Cxcl1, Cxcl5 and Ccl20 mRNA expression in bronchial brushes collected at 2 hours (A). Dnmt3bfl/flCc10Cre and control Dnmt3bfl/fl mice were infected with PAK (5 x 106 CFU) intranasally. Cxcl1, Cxcl5 and Ccl20 mRNA expression in bronchial brushes collected at 2 hours (B). CXCL1, CXCL5 and CCL20 (C), neutrophil counts (D), MPO (E) and bacterial counts (F) in BALF were determined in BALF harvested after 6 or 24 hours. Data are presented as means ± SEM of 8 mice per group at each time point. * p < 0.05.