Extended Data Fig. 6. Antibody escapability and its relationship to other properties.

a, Pairwise scatterplots between all antibody properties discussed in the main text. Select scatterplots from this panel are shown in Figs. 2h–j. Details of each property described in Methods. All axes are oriented such that moving to up on the y-axis and right on the x-axis corresponds to moving in the “preferred” direction for an antibody property (lower neutralization IC50, lower K_D, higher breadth, narrower epitope size, lower escapability, lower total frequency of SARS-CoV-2 escape mutants among sequences on GISAID). b, Additional viral escape selections, as in Fig. 3a. For S309, we also include the E340A mutation identified in selections of authentic SARS-CoV-2 by Cathcart et al.²⁴.