Extended Data Fig. 8. Genetic and structural basis for broad sarbecovirus binding.
a, Quaternary context of the S2H97 epitope. Left, S2H97-bound RBD, with RBD sites colored by S2H97 escape (scale bar, bottom). Right, RBD in the same angle as left, in the closed spike trimer40. The S2H97 epitope is buried with the NTD of the neighboring protomer, requiring extensive RBD opening to enable access to the S2H97 epitope (Fig. 4d). b, Integrative genetic and functional features of the structural epitope of S309. Details as in Fig. 3e,f. c, Occupancy of key S309/RBD contacts during molecular dynamics simulation of S309 bound to the wildtype (42-μs simulation), P337A (56-μs) and P337L (91-μs) mutated RBD. Details as in Fig. 4g. d, Integrative genetic and functional features of the structural epitope of S304. Details as in Fig. 4b.