Table 2:
Unadjusted Patient Outcomes at 28 Days
| Total 1,179 subjects | (A) Continued (n=466) | (B) Discontinued (n=42) | (C) Newly Initiated (n=311) | (D) Never (n=360) | p-value** |
|---|---|---|---|---|---|
| 28-day Outcomes from Presentation to Care | |||||
| Patient status at 28 days, n (%) | |||||
| Deceased* | 78/466 (16.7%) | 14/42 (33.3%) | 30/311 (9.6%) | 32/360 (8.9%) | <0.001 |
| Discharged alive | 252/466 (54.1%) | 20/42 (47.6%) | 176/311 (56.6%) | 257/360 (71.4%) | |
| Transfer to other facility (non-palliative care) | 61/466 (13.1%) | 4/42 (9.5%) | 36/311 (11.6%) | 35/360 (9.7%) | |
| Still hospitalized at 28 days after presentation to care | 75/466 (16.1%) | 4/42 (9.5%) | 69/311 (22.2%) | 36/360 (10.0%) | |
| Days from hospital admission to death, median (IQR) | 10 (6–15) [n=78] | 3 (1–4) [n=14] | 12 (7–16) [n=30] | 6 (3–13) [n=32] | <0.001 |
| Days from hospital admission to discharge or transfer to non-palliative facility, median (IQR) | 7 (4–10) [n=313] | 4 (1–6) [n=24] | 7 (4–10) [n=212] | 5 (3–8) [n=292] | <0.001 |
| Patient events during 28 days of follow-up, n (%) | |||||
| ICU admission | 145/466 (31.1%) | 8/42 (19.0%) | 131/311 (42.1%) | 77/360 (21.4%) | <0.001 |
| Invasive intubation | 122/466 (26.2%) | 6/42 (14.3%) | 110/311 (35.4%) | 65/360 (18.1%) | <0.001 |
| Bacterial Pneumonia | 132/466 (28.3%) | 9/42 (21.4%) | 106/311 (34.1%) | 71/360 (19.7%) | <0.001 |
| Acute Respiratory Distress Syndrome | 112/466 (24.0%) | 5/42 (11.9%) | 105/311 (33.8%) | 61/360 (16.9%) | <0.001 |
| Stroke / Cerebrovascular accident | 3/466 (0.6%) | 1/42 (2.4%) | 3/311 (1.0%) | 2/360 (0.6%) | 0.390 |
| Cardiac arrest | 2/466 (0.4%) | 1/42 (2.4%) | 2/311 (0.6%) | 2/360 (0.6%) | 0.390 |
| Rhabdomyolysis/myositis | 18/466 (3.9%) | 2/42 (4.8%) | 18/311 (5.8%) | 21/360 (5.8%) | 0.499 |
| Liver dysfunction | 80/466 (17.2%) | 11/42 (26.2%) | 71/311 (22.8%) | 64/360 (17.8%) | 0.123 |
IQR (Interquartile range)
*
Deceased includes 3 patients who were discharged to hospice care
**
p-values were calculated comparing all 4 groups using the Kruskal-Wallis test for continuous variables and Fisher’s exact test for categorical variables.