Table 3:
Unadjusted Peak Laboratory Values by Statin Group.
| Total 1,179 subjects | (A) Continued (n=466) | (B) Discontinued (n=42) | (C) Newly Initiated (n=311) | (D) Never (n=360) | p-value* |
|---|---|---|---|---|---|
| Peak Labs, median (IQR) | |||||
| White blood cell count, /μL | 8.7 (6.6–12.5) [n=466] | 7.9 (6.3–16) [n=40] | 9.9 (7.1–15.2) [n=311] | 8.3 (6.2–12.1) [n=349] | 0.001 |
| Aspartate aminotransferase, U/L | 65 (40–119) [n=463] | 60 (32–208) [n=38] | 84 (45–150) [n=311] | 66 (35–127) [n=338] | 0.008 |
| Alanine aminotransferase, U/L | 46 (26–85) [n=463] | 47 (23–121) [n=38] | 68 (31–120) [n=311] | 57 (26–118) [n=338] | <0.001 |
| Total bilirubin, mg/dL | 0.7 (0.5–1.1) [n=463] | 0.5 (0.4–0.8) [n=38] | 0.6 (0.5–1) [n=311] | 0.6 (0.4–0.9) [n=339] | 0.011 |
| Alkaline phosphatase, U/L | 105 (79–166) [n=463] | 101 (77–155) [n=38] | 97 (72–156) [n=311] | 96 (72–140) [n=338] | 0.017 |
| Troponin, ng/L | 23 (10–52) [n=451] | 40 (14–90) [n=38] | 12 (6–29) [n=305] | 8 (6–23) [n=322] | <0.001 |
| C-reactive protein, mg/L | 145 (69–252) [n=459] | 141 (50–231) [n=36] | 151 (82–283) [n=311] | 117 (52–175) [n=330] | <0.001 |
| Erythrocyte sedimentation rate, mm/h | 57 (36–104) [n=426] | 68 (36–90) [n=32] | 72 (41–114) [n=297] | 44 (26–74) [n=295] | <0.001 |
| Creatine kinase, U/L | 178 (85–507) [n=461] | 374 (89–838) [n=36] | 222 (90–636) [n=310] | 173 (78–578) [n=331] | 0.028 |
| D-dimer, ng/mL | 1863 (986–3596) [n=455] | 1944 (1075–7380) [n=37] | 2090 (1038–5098) [n=305] | 1241 (713–3270) [n=329] | <0.001 |
| Absolute lymphocyte count, K/μL | 1.6 (1.1–2.2) [n=466] | 1.5 (1–2.5) [n=40] | 1.9 (1.4–2.4) [n=311] | 1.7 (1.3–2.3) [n=341] | <0.001 |
*
p-values were calculated comparing all 4 groups using the Kruskal-Wallis test for continuous variables and Fisher’s exact test for categorical variables.