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. 2021 Apr 8;47(6):98. doi: 10.3892/ijmm.2021.4931

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Copyright: © Xiao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PINK1 is the target gene of miR-142. (A) Binding sequence of miR-142 and PINK1 was analyzed using bioinformatics software. (B) The targeting association between miR-142 and PINK1 was validated by the dual luciferase report gene assay. The data were analyzed by two-way ANOVA, and the pairwise comparisons following ANOVA were analyzed by Sidak's multiple comparisons test. ^**P<0.01, compared with the NC group. (C) Relative levels of PINK1 were detected by (a) RT-qPCR and (b) western blot analysis, n=3. Data were analyzed by one-way ANOVA, and pairwise comparisons following ANOVA were analyzed by Tukey's multiple comparisons test. ^**P<0.01, compared with the epilepsy group. miR-142, microRNA-142; PINK1, phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-induced putative kinase 1; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; ANOVA, analysis of variance; NC, negative control.