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. 2021 Apr 8;47(6):98. doi: 10.3892/ijmm.2021.4931

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Copyright: © Xiao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PINK1 overexpression is protective for hippocampal neurons in epileptic rats. (A) Relative mRNA and protein levels of PINK1 in the hippocampus of epileptic rats detected by RT-qPCR and western blot analysis, n=3. (B-F) Representative images of H&E staining, Nissl staining, TUNEL assay, EJC staining and Hoechst 33258 nuclear staining, n=6. Data were analyzed by one-way ANOVA, and the pairwise comparisons following ANOVA were analyzed by Tukey's multiple comparisons test. ^**P<0.01, compared with the LV-NC group; ^##P<0.01, compared with the antagomir-miR-142 + siRNA-NC group. miR-142, microRNA-142; PINK1, phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-induced putative kinase 1; RT-qPCR, reverse transcription quantitative polymerase chain reaction; H&E, hematoxylin and eosin; ANOVA, analysis of variance; LV, lentivirus vector; NC, negative control.