Figure 3.

Expression of barrier proteins (tight junction protein 1 [TJP-1], occludin [OCLN], and claudin-1 [CLDN-1]), sodium hydrogen exchanger (solute carrier family 9 member A1 [SLC9A1]), and the bile acid transporter (G-protein–coupled bile acid receptor 1 [GPBAR1]) in ileal biopsies from healthy controls and from patients with constipation-predominant irritable bowel syndrome (IBS-C) or diarrhea-predominant irritable bowel syndrome (IBS-D). These measurements are based on Western blot quantification and 3 group comparisons based on ANOVA on ranks. Note the numerically lower expression of TJP-1 in biopsies from patients with IBS-D compared with healthy controls.