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. 2021 Apr 12;12(4):e00329. doi: 10.14309/ctg.0000000000000329

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© 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Lens for enrichment and network studies analysis of altered expression of messenger RNA (mRNA) in ileal biopsies of healthy controls and patients with constipation-predominant irritable bowel syndrome (IBS-C) and diarrhea-predominant irritable bowel syndrome (IBS-D). Note in the left panel the connectivity of mechanisms involved in ion absorption or secretion (particularly, solute carrier family 9 member A1 and PATJ [also known as inactivation-no-afterpotential D-like) as well as the unconnected downregulated G-protein–coupled bile acid receptor 1 (GPBAR1) in IBS-C. The right panel shows connectivity for the increased mRNA expression related to barrier function, as well as cell development, kinetics, and repair. CALR, calreticulin; CLDN, claudin; CTNNB1, catenin beta 1; FN1, fibronectin 1; KITLG, KIT ligand; MYLK, myosin light chain kinase; PPP1CB, protein phosphatase 1 catalytic subunit beta; SOS1, Sons of Sevenless (Drosophila) homolog 1; TFF1, trefoil factor 1; TJP1, tight junction protein 1; TLR, toll-like receptor.