Table 1.
Patient demographics and measurements of colonic transit and bile acid parameters available
| Healthy (N = 14) | IBS-C (N = 17) | IBS-D (N = 11) | Pa | |
| Female sex, n (%) | 6 (42.9) | 17 (100) | 10 (90.9) | |
| Age, yr (SE) | 47 (3.2) | 52 (2.9) | 48.3 (3.6) | |
| Race, n (%) | ||||
| White | 14 (100) | 17 (100) | 9 (81.8) | |
| Black or African American | 1 (9.1) | |||
| Other | 1 (9.1) | |||
| Colonic transit, median (IQR) | N = 5 | N = 12 | N = 9 | |
| 24 hr | 2.28 (1.43–4.2) | 1.72 (1.52–1.87) | 3.35 (2.37–4.30) | <0.001 |
| 48 hr | 2.69 (2.25–3.06) | 5.0 (4.83–5.0) | 0.003 | |
| 48h fecal bile acids, median (IQR) | N = 4 | N = 5 | ||
| % CDCA+CA | 0.7 (7.3) | ND | 1.7 (20) | |
| Total | 1,063 (1,611) | 2,199 (2,138) | ||
| Serum 7aC4 | N = 13 | N = 15 | N = 11 | |
| Mean (SD) | 15.5 (11.2) | 22.5 (24.2) | 39.4 (33.7) | |
| Median (IQR) | 14.8 (16.9) | 6.4 (35.7) | 27.7 (64.5) |
7aC4, 7 alpha-hydroxy-4-cholesten-3-one; CA, cholic acid; CDCA, chenodeoxycholic acid; IBS-C, constipation-predominant irritable bowel syndrome; IBS-D, diarrhea-predominant irritable bowel syndrome; IQR, interquartile range; ND, not done.
a
P value based on the Mann-Whitney rank-sum test for IBS-D compared with IBS-C groups.