Table 3.
Fold change and fold regulation of mRNA according to group in ileal biopsies IBS-C vs HC and IBS-D vs IBS-C
| Symbol | Average fold change IBS-C/HC | Average fold regulation IBS-C/HC | Average fold change IBS-D/IBS-C | Average fold regulation IBS-D/IBS-C |
| Cell adhesion, tight junctions, or barrier function | ||||
| TFF1 | 0.580 | −1.724 | 2.109 | 2.109 |
| FN1 | 0.716 | −1.397 | 1.734 | 1.734 |
| CLDN1 | 0.610 | −1.640 | 2.150 | 2.150 |
| CLDN12 | 0.765 | −1.307 | 1.415 | 1.415 |
| PVRL3 (Nectin3) | 0.796 | −1.256 | 1.331 | 1.331 |
| OCLN | 0.878 | −1.139 | 1.328 | 1.328 |
| MYLK | 0.767 | −1.305 | 1.365 | 1.365 |
| TJP1 | 0.896 | −1.117 | 1.425 | 1.425 |
| FGFR4 | 1.062 | 1.062 | 1.367 | 1.367 |
| Neurotransmitters, exchangers, and receptors | ||||
| GPBAR1 | 0.674 | −1.483 | 1.285 | 1.285 |
| HNMT | 0.685 | −1.461 | 1.423 | 1.423 |
| HRH1 | 0.932 | −1.073 | 1.217 | 1.217 |
| HRH2 | 0.644 | −1.554 | 2.260 | 2.260 |
| SLC9A1 | 1.300 | 1.300 | 1.024 | 1.024 |
| KITLG | 0.754 | −1.327 | 1.672 | 1.672 |
| INADL (PATJ) | 1.262 | 1.262 | 0.868 | −1.152 |
| SOS1 | 0.914 | −1.094 | 1.256 | 1.256 |
| Cell kinetics | ||||
| CTNNB1 | 1.253 | 1.253 | 0.865 | −1.156 |
| CALR | 0.821 | −1.218 | 1.556 | 1.556 |
| PPP1CB | 0.910 | −1.099 | 1.166 | 1.166 |
| Innate immunity and inflammation | ||||
| TLR1 | 0.636 | −1.573 | 1.952 | 1.952 |
| TLR3 | 0.720 | −1.389 | 1.182 | 1.182 |
| TLR5 | 0.768 | −1.302 | 1.486 | 1.486 |
| IL15 | 0.807 | −1.239 | 1.279 | 1.279 |
Average fold regulation was calculated by the formula: −(1/fold change), if fold change <1. When the fold change is >1, the fold change and fold regulation are equal.
CALR, calreticulin; CLDN1, claudin-1; CLDN12, claudin-12; CTNNB1, catenin beta 1; FGFR4, fibroblast growth factor receptor 4; FN1, fibronectin 1; GPBAR1, G-protein–coupled bile acid receptor 1; HC, healthy controls; HNMT, histamine n-methyl transferase; HRH1, histamine receptor H1; HRH2, histamine receptor H2; IBS-C, constipation-predominant irritable bowel syndrome; IBS-D, diarrhea-predominant irritable bowel syndrome; IL15, interleukin 15; INADL, inactivation-no-afterpotential D-like (also known as PATJ); KITLG, KIT ligand; mRNA, messenger RNA; MYLK, myosin light chain kinase; OCLN, occludin; PPP1CB, protein phosphatase 1 catalytic subunit beta; PVRL3, poliovirus-receptor-related 3 (also known as nectin 3); SLC9A1, solute carrier family 9 member A1; SOS1, Sons of Sevenless (Drosophila) homolog 1; TFF1, trefoil factor 1;TJP1, tight junction protein 1; TLR1, toll-like receptor 1; TLR3, toll-like receptor 3; TLR5, toll-like receptor 5.