Table 4.
Comparison of 5 proteins in ileal mucosa of patients with IBS-C or IBS-D expressed as ratios relative to biopsies from healthy controls estimated within Western blots
| Protein | Mean | Median | 95% CI of median |
| IBS-C group | |||
| TJP-1 | 0.724 | 0.515 | 0.327–0.795 |
| SLC9A1 | 1.054 | 0.773 | 0.179–0.974 |
| OCLN | 0.768 | 0.467 | 0.199–0.850 |
| GPBAR1 | 0.762 | 0.834 | 0.579–1.062 |
| CLDN | 1.302 | 1.166 | 0.281–2.402 |
| IBS-D group | |||
| TJP-1 | 0.619 | 0.471 | 0.280–0.949 |
| SLC9A1 | 0.829 | 0.807 | 0.654–0.903 |
| OCLN | 1.007 | 0.800 | 0.517–1.361 |
| GPBAR1 | 0.980 | 0.870 | 0.664–1.237 |
| CLDN | 0.700 | 0.242 | 0.0395–1.626 |
Note the reduced expression shown by ratios that do not overlap 1.0 in the 95% CIs for TJP-1, SLC9A1 (for both IBS-C and IBS-D) and for OCLN in IBS-C.
CI, confidence interval; CLDN, claudin; GPBAR1, G-protein–coupled bile acid receptor 1; IBS-C, constipation-predominant irritable bowel syndrome; IBS-D, diarrhea-predominant irritable bowel syndrome; OCLN, occluding; SLC9A1, solute carrier family 9 member A1; TJP1, tight junction protein 1.