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. 2021 Apr 1;10:e67267. doi: 10.7554/eLife.67267

Figure 5. IGF-1 decreases the frequency of mEPSC.

Figure 5.

(A) Representative traces recorded at −60 mV in IL-L5PNs from animals that showed fear extinction, in the presence of 1 µM TTX, 50 µM PiTX, and 5 μM CPG-55845. Asterisks denote mEPSC events. Note the decreased mEPSCs frequency induced by IGF-1. (B) Bar diagram of the summary data showing mean mEPSCs frequency from Ext-Saline (black, n = 5 cells/2 animals); Ext-IGF-1 (red, n = 6/3 animals); and Ext-NVP +IGF-1 (gray, n = 6/3 animals). One-way ANOVA with post hoc Tukey's multiple comparisons test. (C) Cumulative probability plots of mean inter-mEPSC interval in Ext-Saline (black); Ext-IGF-1 (red); and Ext-NVP +IGF-1 (gray) (same cells as in B). Note that IGF-1 increased the mean inter-mEPSC interval (p<0.05; Kolmogorov–Smirnov test). (D) Bar diagram of the summary data showing mean mEPSCs amplitude (same cells as in B). (E) Cumulative probability plots of mean amplitude-mEPSC in Ext-Saline (black); Ext-IGF-1 (red); and Ext-NVP +IGF-1 (gray). Note that IGF-1 does not change the mean mEPSCs amplitude (same cells as in B).

Figure 5—source data 1. Source data for Figure 5: IGF-1 decreases the frequency of mEPSC.