Table 4.
Prediction of DR and VTDR by TyG index and four biochemical blood parameters
| Cases/controls, n | AUC (95% CI) | P | Cutoff | Sensitivity | Specificity | |
|---|---|---|---|---|---|---|
| DR | 596/1516 | |||||
| HbA1c, %, (mmol/mol) | 0.515 (0.487–0.542) | 0.296 | 9.05 (75.4) | 0.350 | 0.696 | |
| FPG (mg/dL, mmol/L) | 0.529 (0.502–0.556) | 0.035 | 182.79 (10.16) | 0.354 | 0.703 | |
| TGs (mg/dL) | 0.533 (0.507–0.560) | 0.017 | 170.36 | 0.443 | 0.629 | |
| HOMA-IR | 0.534 (0.507–0.561) | 0.016 | 3.47 | 0.588 | 0.480 | |
| TyG index | 0.534 (0.507–0.561) | 0.015 | 9.67 | 0.363 | 0.710 | |
| VTDR | 63/1516 | |||||
| HbA1c, %, (mmol/mol) | 0.526 (0.458–0.594) | 0.485 | 10.05 (86.3) | 0.232 | 0.873 | |
| FPG (mg/dL, mmol/L) | 0.608 (0.550–0.666) | 0.004 | 167.85 (9.33) | 0.420 | 0.825 | |
| TGs (mg/dL) | 0.588 (0.528–0.648) | 0.018 | 210.19 | 0.316 | 0.873 | |
| HOMA-IR | 0.580 (0.513–0.647) | 0.031 | 3.83 | 0.513 | 0.651 | |
| TyG index | 0.624 (0.569–0.679) | 0.001 | 9.77 | 0.319 | 0.937 |
Abbreviations: DR, diabetic retinopathy; VTDR, vision-threateningDR; TyG, triglyceride–glucose; AUC, area under curve; HbA1c, glycated hemoglobin; FPG, fasting plasma glucose; TGs, triglycerides; HOMA-IR, homeostasis-model assessment of insulin resistance.