Table 4.
Univariate and Multivariate Analyses of Overall Survival (OS) in the Elderly EC Patients
| Characteristics | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR(95% CI) | P | HR(95% CI) | P | |
| Gender (Male) | 1.029(0.594–1.781) | 0.920 | ||
| Age(>70) | 1.402(0.902–2.180) | 0.133 | ||
| Smoke (Yes) | 1.013(0.645–1.592) | 0.956 | ||
| Alcohol drinking (Yes) | 0.842(0.538–1.316) | 0.450 | ||
| BMI (Normal+High) | 0.669(0.414–1.081) | 0.101 | ||
| Lymphatic metastasis (Yes) | 2.756(1.728–4.396) | <0.001 | 1.905(1.146–3.166) | 0.013 |
| Cancer embolus (Yes) | 2.564(1.589–4.137) | <0.001 | 1.540(0.900–2.635) | 0.115 |
| Perineural invasion (Yes) | 1.334(0.666–2.673) | 0.416 | ||
| Differentiation (Poor) | 2.042(1.281–3.256) | 0.003 | 1.781(1.075–2.950) | 0.025 |
| Tumor depth(pT3+pT4) | 1.961(1.225–3.139) | 0.005 | 1.184(0.715–1.962) | 0.241 |
| L3SMI (high-L3SMI) | 0.366(0.232–0.577) | <0.001 | 0.536(0.318–0.903) | 0.019 |
| GNRI(>96.6) | 0.535(0.338–0.845) | 0.007 | 1.017(0.562–1.838) | 0.957 |
| PNI(>45.35) | 0.555(0.356–0.865) | 0.009 | 0.807(0.483–1.346) | 0.410 |
| Tumor size(>4cm) | 1.096(0.705–1.704) | 0.683 | ||
| Pathology (Adenocarcinoma) | 1.156(0.467–2.860) | 0.754 | ||
| ALI (high) | 0.434(0.256–0.735) | 0.002 | 0.537(0.300–0.962) | 0.037 |
| Tumor location | 0.611 | |||
| Upper | 1 | |||
| Middle | 0.736(0.314–1.727) | 0.482 | ||
| Lower | 0.647(0.268–1.565) | 0.334 | ||
Note: Bold values indicate statistically significant values.
Abbreviations: GNRI, Geriatric Nutritional Risk Index; PNI, prognostic nutritional index; L3SMI, L3 skeletal muscle index; ALI, advanced lung cancer inflammation index; EC, esophageal cancer; HR, hazard ratio.