Table 1.
Baseline Clinical Characteristics
| Variables | Metformin Exposure (n = 719) | Metformin Non-Exposure (n = 342) | p-value |
|---|---|---|---|
| Male | 419 (66.6%) | 220 (64.3%) | 0.057 |
| Age | 59.0±9.9 | 60.6±9.9 | 0.834 |
| BMI | 707 | 328 | 0.502 |
| <18.5 | 23 (3.3%) | 18 (5.5%) | |
| 18.5–22.9 | 151 (21.4%) | 93 (28.4%) | |
| 23–24.9 | 144 (20.4%) | 78 (23.8%) | |
| ≥ 25 | 389 (55.0%) | 139 (42.4%) | |
| Child–Pugh class | <0.001 | ||
| A | 629 (87.5%) | 257 (75.2%) | |
| B | 72 (10.0%) | 71 (20.8%) | |
| C | 18 (2.5%) | 14 (4.1%) | |
| HbA1c | 699 | 325 | 0.645 |
| <7.5% | 453 (64.8%) | 213 (65.5%) | |
| ≥7.5% | 246 (35.2%) | 112 (32.8%) | |
| Etiology of cirrhosis | 0.568 | ||
| Alcoholism | 143 (19.9%) | 84 (24.6%) | |
| HBV | 227 (31.6%) | 115 (45.3%) | |
| HCV | 133 (18.5%) | 60 (17.5%) | |
| NASH | 136 (18.9%) | 34 (9.9%) | |
| Others | 80 (11.1%) | 49 (14.3%) | |
| Alcohol | 675 | 334 | 0.230 |
| No | 374 (55.4%) | 162 (48.5%) | |
| Yes | 199 (29.5%) | 107 (32.0%) | |
| Quit ≥5 years | 102 (15.1%) | 65 (19.5%) | |
| Smoking | 605 | 301 | 0.004 |
| No | 428 (70.7%) | 189 (62.8%) | |
| Yes | 93 (15.4%) | 48 (16.0%) | |
| Quit ≥5 years | 84 (13.9%) | 64 (21.3%) |