Table 2.
Comparison between groups at different time points
| Pre-chemotherapy | p1 | p2 | p3 | Post-chemotherapy | p1 | p2 | p3 | Difference between post-chemotherapy and pre-chemotherapy | p1 | p2 | p3 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Responder group | Poor-responder group | Responder group | Poor-responder group | Responder group | Poor-responder group | ||||||||||
| Tumor area | |||||||||||||||
| Ktrans/min | 0.47 (0.39, 0.55) | 0.59 (0.27, 0.72) | NS | NS | NS | 0.21 (0.15, 0.23) | 0.40 (0.23, 0.57) | 0.009 | NS | 0.04 | − 0.24 (− 0.31, − 0.20) | − 0.065 (− 0.2, − 0.042) | 0.0007 | 0.04 | 0.006 |
| Kep/min | 2.03 (1.27, 2.646) | 1.54 (0.86, 2.61) | NS | NS | NS | 1.47 (1.03, 2.23) | 1.37 (1.056, 2.963) | NS | NS | NS | − 0.51 (− 0.65, 0.21) | 0.25 (− 0.08, 0.55) | NS | NS | NS |
| Ve | 0.35 (0.22, 0.43) | 0.36 (0.28, 0.60) | NS | NS | NS | 0.33 (0.23, 0.47) | 0.43 (0.22, 0.58) | NS | NS | NS | − 0.016 (− 0.11, 0.18) | − 0.041 (− 0.13, 0.11) | NS | NS | NS |
| IAUC | 8.15 (5.94, 19.56) | 8.96 (6.42, 10.56) | NS | NS | NS | 6.76 (5.22, 9.00) | 7.29 (5.68, 10.21) | NS | NS | NS | − 0.72 (− 3.23, 0.97) | −0.84(−2.7,0.30) | NS | NS | NS |
| ADC (× 10−3) | 1.08 (0.89, 1.33) | 1.35 (1.18, 1.48) | 0.001 | 0.05 | 0.006 | 1.68 (1.35, 2.01) | 1.65 (1.40, 1.77) | NS | NS | NS | 0.73 (0.32, 1.0) | 0.33 (0.24, 0.42) | 0.015 | NS | NS |
| Peritumoral area | |||||||||||||||
| Ktrans/min | 0.26 (0.21, 0.33) | 0.36 (0.18, 0.46) | NS | NS | NS | 0.13 (0.10, 0.17) | 0.20 (0.11, 0.32) | NS | NS | NS | − 0.14 (− 0.19, − 0.10) | − 0.09 (− 0.17, − 0.04) | 0.04 | NS | NS |
| Kep/min | 1.49 (1.17, 1.97) | 0.75 (0.59, 1.97) | 0.037 | NS | NS | 1.57 (0.74, 3.09) | 1.39 (0.53, 1.60) | NS | NS | NS | 0.26 (− 0.75, 1.38) | 0.12 (− 0.52, 0.91) | NS | NS | NS |
| Ve | 0.23 (0.15, 0.26) | 0.38 (0.21, 0.75) | 0.025 | NS | NS | 0.12 (0.07, 0.26) | 0.27 (0.26, 0.29) | 0.021 | NS | NS | − 0.066 (− 0.13, 0.031) | − 0.08 (− 0.46, − 0.002) | NS | NS | NS |
| IAUC | 7.0 (2.53, 10.33) | 5.90 (4.88, 12.42) | NS | NS | NS | 5.64 (3.92, 8.35) | 7.51 (3.86, 9.41) | 0.028 | NS | NS | − 2.12 (− 3.64, − 0.56) | − 1.91 (− 3.37, − 0.39) | NS | NS | NS |
| ADC (× 10−3) | 1.35 (1.04, 1.54) | 1.66 (1.33, 1.81) | NS | NS | NS | 2.35 (2.15, 2.51) | 1.98 (1.86, 2.09) | 0.002 | 0.1 | 0.01 | 0.89 (0.67, 1.31) | 0.26 (0.13, 0.45) | 0.0015 | 0.075 | 0.008 |
Non-parametric Wilcoxon’s signed-rank tests were used to examine the difference of ADC and eight DCE-MRI parameters. Mann-Whitney tests were used to examine the difference of each parameter between groups. Multiple comparisons (50 times) were performed. p1: uncorrection; p2: Bonferroni’s correction; p3: false discovery rate correction. NS non-significant