Table 3.
Comparison between different time points
| Responder group | p1 | p2 | p3 | Poor-responder group | p1 | p2 | p3 | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Pre-chemotherapy | Post-chemotherapy | Pre-chemotherapy | Post-chemotherapy | |||||||
| Tumor area | ||||||||||
| Ktrans/min | 0.47 (0.39, 0.55) | 0.21 (0.15, 0.23) | 0.0006 | 0.03 | 0.006 | 0.592 (0.267, 0.718) | 0.395 (0.228, 0.567) | NS | NS | NS |
| Kep/min | 2.03 (1.27, 2.64) | 1.46 (1.03, 2.23) | NS | NS | NS | 1.544 (0.856, 2.610) | 1.371 (1.056, 2.963) | NS | NS | NS |
| Ve | 0.35 (0.22, 0.43) | 0.33 (0.23, 0.47) | NS | NS | NS | 0.360 (0.278, 0.602) | 0.428 (0.222, 0.582) | NS | NS | NS |
| IAUC | 8.15 (5.94, 19.6) | 6.76 (5.22, 8.99) | NS | NS | NS | 8.962 (6.422, 10.560) | 7.293 (5.684, 10.210) | NS | NS | NS |
| ADC (× 10−3) | 1.08 (0.89, 1.33) | 1.68 (1.35, 2.01) | 0.000002 | 0.0001 | 0.0001 | 1.350 (1.180, 1.480) | 1.650 (1.400, 1.770) | 0.0002 | 0.001 | 0.003 |
| Peritumoral area | ||||||||||
| Ktrans/min | 0.26 (0.21, 0.33) | 0.13 (0.10, 0.17) | 0.0001 | 0.006 | 0.002 | 0.362 (0.178, 0.464) | 0.199 (0.109, 0.316) | NS | NS | NS |
| Kep/min | 1.49 (1.17, 1.97) | 1.57 (0.74, 3.09) | NS | NS | NS | 0.753 (0.587, 1.969) | 1.391 (0.534, 1.596) | NS | NS | NS |
| Ve | 0.23 (0.15, 0.26) | 0.12 (0.07, 0.26) | NS | NS | NS | 0.377 (0.206, 0.751) | 0.269 (0.257, 0.291) | NS | NS | NS |
| IAUC | 7.01 (2.53, 10.33) | 5.64 (3.92, 8.35) | NS | NS | NS | 5.945 (4.882, 12.420) | 7.511 (3.857, 9.406) | NS | NS | NS |
| ADC (× 10−3) | 1.35 (1.04, 1.54) | 2.35 (2.15, 2.51) | 0.00004 | 0.002 | 0.001 | 1.655 (1.325, 1.810) | 1.980 (1.858, 2.085) | 0.0008 | 0.04 | 0.006 |
Non-parametric Wilcoxon’s signed-rank tests were used to examine the difference of ADC and eight DCE-MRI parameters. Mann-Whitney tests were used to examine the difference of each parameter between different time points. Multiple comparisons (50 times) were performed. p1: uncorrection; p2: Bonferroni’s correction; p3: false discovery rate correction. NS non-significant