Table 3.
Median results for sleep parameters for overnight polysomnogram results by visit in the per protocol population with reduced ejection fraction heart failure
| Treatment (n=26) | Control (n=34) | Between group P-value | |||||
|---|---|---|---|---|---|---|---|
| Variable | Baseline | 6 Months | Change | Baseline | 6 Months | Change | |
| AHI (events/hour) |
47 41, 58 |
17 9, 35 |
−24 −38, −13 |
39 32, 52 |
41 33, 52 |
1 −4, 15 |
<.001 |
| CAI (events/hour) |
29 14, 41 |
1 0, 3 |
−22 −40, −14 |
20 14, 31 |
22 12, 30 |
−3 −9, 5 |
<.001 |
| ODI4% (events/hour) |
42 33, 53 |
17 7, 36 |
−21 −30, −7 |
34 26, 48 |
40 28, 51 |
3 −6, 14 |
<.001 |
| Minutes of Sleep with O2 | 31 | 8 | −21 | 27 | 34 | −0 | 0.037 |
| Saturation<90% (minutes) | 16, 79 | 1, 33 | −44, −4 | 4, 65 | 11, 65 | −31, 28 | |
| Percent of Sleep with O2 | 9 | 4 | −6 | 9 | 12 | −0 | 0.083 |
| Saturation<90% (%) | 5, 22 | 0, 17 | −9, −2 | 2, 18 | 3, 26 | −11, 8 | |
| Average O2 Saturation | 93.1 | 93.8 | 1.1 | 92.7 | 92.7 | 0.2 | 0.026 |
| during sleep (%) | 91.3, 94.4 | 92.3, 95.1 | −0.4, 1.7 | 91.8, 94.5 | 91.5, 93.4 | −1.6, 0.9 | |
| Lowest O2 Saturation | 81.0 | 81.5 | 1.0 | 82.0 | 80.0 | −1.0 | 0.079 |
| during sleep (%) | 76.0, 83.0 | 76.0, 87.0 | −3.0, 6.0 | 78.0, 85.0 | 75.0, 84.0 | −6.0, 2.0 | |
Reported as median and interquartile range
P-value from Mann-Whitney test for difference in change from baseline between groups (2-sided)
AHI apnea-hypopnea index; CAI central apnea index; ODI4 oxygen desaturation ≥4% index; O2 oxygen