Table 1.
Clinical Characteristics
| Measure | NH controls | CM | PoTS-ALL | p-value | ||
|---|---|---|---|---|---|---|
| CM vs NH | PoTS vs NH | CM vs PoTS | ||||
| N | 20 | 30 | 30 | |||
| Sex (F/M, %F) | 17/3, 85% | 25/5, 80% | 27/3, 90% | .87 Δ | .59 Δ | .45 Δ |
| Age, years (median, range) | 28.5; 17–57 | 30.5; 15–72 | 26.0; 15–59 | .21 ¥ | .79 ¥ | .09 ¥ |
| Heart rate increment, head-up tilt table, bpm (mean; SD) | 16; 11 | 21; 12 | 39; 10 | .50 ¥ | <.00001 ¥ | .0001 ¥ |
| COMPASS-31, total score (median; IQR) | 4; 14 | 34; 21 | 52; 14 | <.00001 ¥ | <.00001 ¥ | .0005 ¥ |
| Domain scores: | ||||||
| Pupillomotor | 0; 1 | 3; 2 | 3; 2 | * | * | |
| Gastrointestinal | 1; 2 | 7; 6 | 10; 7 | * | * | |
| Orthostatic | 0; 3 | 20; 12 | 28; 8 | * | * | * |
| Bladder | 0; 0 | 0; 1 | 1; 2 | * | ||
| Vasomotor | 0; 0 | 2; 6 | 6; 4 | * | ||
| Secretomotor | 0; 0 | 0; 2 | 2; 3 | * | ||
bpm, beats per minute; CM, chronic migraine; F, female; IQR, inter-quartile range; M, male; NH, non-headache; PoTS, postural tachycardia syndrome; SD, standard deviation.
Δ
chi-square statistic
¥
two-tailed Mann-Whitney U test
*
significant following correction for multiple comparisons across domains (Bonferroni threshold p<.007)