Table 2.
Vehicle (n=22) | Single dose (n=24) | Multiple doses (n=20) | |
---|---|---|---|
EDV (μl) | 81.1 ± 3.7 | 80.2 ± 3.0 | 72.4 ± 3.4 |
ESV (μl) | 66.4 ± 3.2 | 62.9 ± 2.6 | 53.7 ± 2.8# |
SV (μl) | 21.0 ± 1.4 | 24.0 ± 1.3 | 26.9 ± 1.1# |
+dP/dt (mmHg/s) | 5016 ± 151 | 5260 ± 176 | 5651 ± 136# |
−dP/dt (mmHg/s) | −5019 ± 178 | −5192 ± 184 | −5402 ± 138 |
EF (%) | 25.9 ± 1.1 | 30.0 ± 1.2 | 37.6 ± 1.3#* |
Ees (mmHg/μl) | 4.8 ± 0.1 | 5.5 ± 0.2 | 7.5 ± 0.3#* |
EDV indicates end-diastolic volume; ESV, end-systolic volume; SV, stroke volume; ±dP/dt, maximum and minimum rate of pressure change; EF, ejection fraction; Ees, end-systolic elastance.
P<0.05 vs. vehicle;
P<0.05 vs. single dose.
Data are means ± SEM.