TABLE 2.
Total sample sizes to detect treatment effects (25% and 40% reductions in score change) in sample of 26 MCI and AD‐dementia participants with complete longitudinal cognitive data for UDS subtests
| Measure | n | 25% | 40% |
|---|---|---|---|
| UDS measures | |||
| UDS3‐EF | 26 | 728 | 286 |
| TMT A | 26 | 9016 | 3524 |
| TMT B | 26 | 1966 | 770 |
| Digit span backward | 26 | 1988 | 778 |
| F‐words | 26 | 1822 | 714 |
| L‐words | 26 | 4994 | 1952 |
| Animal fluency | 26 | 34680 | 13548 |
| Vegetable fluency | 26 | 3654 | 1428 |
| Common measures | |||
| CDR Sum of Boxes | 24 | 4640 | 1814 |
| MoCA | 25 | 4222 | 1650 |
| MMSE | 20 | 13296 | 5196 |
Note: We also present commonly used outcome measures, when available (ns 20 to 25), to provide an independent reference against which to illustrate the power of the UDS3‐EF for tracking longitudinal change.
Abbreviations: AD‐dementia; Alzheimer's disease dementia; CDR, Clinical Dementia Rating Scale; MCI, mild cognitive impairment; MMSE, Mini‐Mental State Examination; MoCA, Montreal Cognitive Assessment; TMT, Trail Making Test; UDS3‐EF, Uniform Data Set v3.0 Executive Function composite score.