Lower UPSIT scores were associated with greater 11C-PBR28 binding when all participants were included in medial temporal cortex (r = −0.58, p < 0.01) and combined middle and inferior temporal gyri (r = −0.47, p < 0.01). Correlations remained when only amyloid-positive participants were included (medial temporal cortex: r = −0.74, p < 0.01; combined middle and inferior temporal gyri: r = −0.47, p = .02) but not when only amyloid-negative participants were included. Data corrected for age, sex, and TSPO genotype.