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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Med Res Rev. 2020 Dec 5;41(3):1375–1426. doi: 10.1002/med.21763

FIGURE 3.

FIGURE 3

The determination of SARS-CoV-2 3CLpro and RdRp crystal structures facilitates the design and development of SARS-CoV-2 inhibitors. (A) The crystal structure of SARS-CoV-2 3CLpro in complex with a peptide-aldehyde inhibitor (PDB: 6M0K). (B) The cryo-EM structure of SARS-CoV-2 RdRp in complex with a template-primer RNA and remdesivir (PDB: 7BV2). 3CLpro, 3C-like protease; cryo-EM, cryogenic electron microscopy; RdRp, RNA-dependent RNA polymerase; SARS-CoV, severe acute respiratory syndrome coronavirus