Skip to main content
. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: J Autoimmun. 2021 Feb 27;119:102619. doi: 10.1016/j.jaut.2021.102619

Figure 3. Treg generation and expansion.

Figure 3.

Increased Treg frequencies noted in AIH patients at remission indicate that these cells could be restored, at least to some extent. Previous studies have shown that Tregs could be expanded in vitro using polyclonal stimuli, i.e. high dose IL-2 and anti-CD3/anti-CD28 T cell expander (polyclonal expansion); generation of Tregs with liver autoantigen specificity could be obtained upon Treg co-culture with semi-mature dendritic cells presenting the autoantigenic peptide of interest. Recent work has reported the possibility to expand Tregs using low dose IL-2 in vivo. Further work is, however needed to validate all of these approaches.