Extended Data Fig. 6 |. Variants that strongly influence inferred selection at other sites often act across large genomic distances.

Plot of all linkage effects on inferred selection coefficients $\Delta {\widehat{s}}_{ij}$ for which $\left|\Delta {\widehat{s}}_{ij}\right|>0.004$. One plot is shown for each sequencing region, for each individual. These strong effects of linkage on inferred selection coefficients can act at long range across the genome. Approximately 40% of highly influential variants, characterized by strong effects on inferred selection at other sites, lie within identified CD8⁺ T cell epitopes. The 5′ region for individual CH607 is not shown because no $\Delta {\widehat{s}}_{ij}$ values are larger than the cutoff.