Skip to main content
. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Nat Biotechnol. 2020 Nov 30;39(4):472–479. doi: 10.1038/s41587-020-0737-3

Fig. 6 |. complex patterns of selection in HiV-1 env following superinfection in an individual who develops broadly neutralizing antibodies.

Fig. 6 |

a, Multiple variants, including several from the superinfecting strain of the virus, rise and fall in frequency within the epitope targeted by the VRC26 lineage of antibodies. b, Inferred selection in CAP256 HIV-1 Env sequences. Inferred selection coefficients are plotted in tracks. Coefficients of TF nucleotides are normalized to zero. Tick marks denote polymorphic sites. Inner links, shown for sites connected to the VRC26 epitope, have widths proportional to matrix elements of the inverse of the integrated covariance. Linkage is extensive due to the struggle for dominance in the viral population between the TF, superinfecting and recombinant strains. c, Map of inferred selection within the VRC26 epitope, consisting of codons 160–171 in Env.