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. 2021 Apr 13;11:8089. doi: 10.1038/s41598-021-87600-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Saliva biomarkers to classify FD and HC groups. (a) Saliva genus level LEfSe analysis in FD and HC. (b) Saliva microbiota species-level microbiota biomarkers in FD and HC groups. Linear discriminant analysis (LDA) score (less strict: 2; more strict: 4) representing significantly different biomarkers between FD and HC groups. The length of the bar chart represents the significance of the different species.